Molecular Profile Detail


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Profile Name FGFR2 - CCDC6
Gene Variant Detail

FGFR2 - CCDC6 (gain of function)

Relevant Treatment Approaches FGFR Inhibitor (Pan) FGFR2 Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 - CCDC6 FGFR3 - TACC3 adrenal carcinoma predicted - sensitive Erdafitinib Case Reports/Case Series Actionable In a Phase I trial, Balversa (erdafitinib) treatment resulted tumor shrinkage and no disease progression for 10 months in an adrenal carcinoma patient harboring FGFR3-TACC3 and FGFR2-CCDC6 fusions (PMID: 26324363; NCT01703481). 26324363
FGFR2 - CCDC6 FGFR2 N549D FGFR2 N549K FGFR2 V564I cholangiocarcinoma predicted - resistant Pemigatinib Case Reports/Case Series Actionable In a Phase I trial (FIGHT-101), a cholangiocarcinoma patient harboring FGFR2-CCDC6 experienced disease progression after initially responding to Pemazyre (pemigatinib), and was found to have acquired FGFR2 N549K, FGFR2 N549D, and FGFR2 V564I (PMID: 35176457; NCT02393248). 35176457