Profile Name | NOTCH1 E1567K |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | NOTCH1 E1567K | osteosarcoma | sensitive | MRK-003 | Preclinical | Actionable | In a preclinical study, MRK-003 inhibited Notch1 signaling in a luciferase reporter assay in osteosarcoma cell lines overexpressing NOTCH1 E1567K in culture (PMID: 25104330). | 25104330 |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status |
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