Molecular Profile Detail

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Profile Name IDH1 mutant
Gene Variant Detail

IDH1 mutant (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATRX loss IDH1 mut high grade glioma predicted - sensitive Gemcitabine + Radiotherapy Phase I Actionable In a Phase I trial, Gemzar (gemcitabine) plus radiation therapy resulted in median overall survival of 73.5 months in 7 high-grade glioma patients with IDH mutated, non-codeleted tumors with ATRX loss (PMID: 26853339). 26853339
ATRX loss IDH1 mut malignant astrocytoma not applicable N/A Guideline Diagnostic ATRX deficiency in combination with IDH mutation aids in the diagnosis of astrocytoma (NCCN.org). detail...