Molecular Profile Detail

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Profile Name MYD88 mutant
Gene Variant Detail

MYD88 mutant (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MYD88 mutant MALT lymphoma not applicable N/A Guideline Diagnostic MYD88 mutations aid in the diagnosis of MALT lymphoma (NCCN.org). detail...
MYD88 mutant marginal zone B-cell lymphoma not applicable N/A Guideline Diagnostic MYD88 mutations are used to differentiate Waldenstroem's macroglobulinemia from marginal zone B-cell lymphoma in the presence of plasmacytic differentiation (NCCN.org). detail...
MYD88 mutant splenic marginal zone lymphoma not applicable N/A Guideline Diagnostic MYD88 mutations aid in the diagnosis of splenic marginal zone lymphoma (NCCN.org). detail...
MYD88 mutant lymphoplasmacytic lymphoma not applicable N/A Clinical Study Diagnostic MYD88 mutations are used in the diagnosis of lymphoplasmacytic lymphoma (Guidelines, PMID: 22944768, PMID: 26230596). detail... 26230596 22944768
MYD88 mutant nodal marginal zone lymphoma not applicable N/A Guideline Diagnostic MYD88 mutations aid in the diagnosis of nodal marginal zone lymphoma (NCCN.org). detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT03225716 Phase Ib/II Ibrutinib + Ulocuplumab A Study of Ulocuplumab And Ibrutinib in Symptomatic Patients With Mutated CXCR4 Waldenstrom's Macroglobulinemia Active, not recruiting
NCT04273139 Phase II Ibrutinib + Venetoclax Ibrutinib + Venetoclax in Untreated WM Recruiting
NCT04115059 Phase I Dasatinib Dasatinib In Waldenstrom Macroglobulinemia Recruiting