Molecular Profile Detail


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Profile Name FLT3 exon 14 ins FLT3 M837G FLT3 S838R FLT3 D839H
Gene Variant Detail

FLT3 D839H (unknown)

FLT3 exon 14 ins (gain of function - predicted)

FLT3 M837G (unknown)

FLT3 S838R (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 M837G FLT3 S838R FLT3 D839H leukemia predicted - resistant Pexidartinib Case Reports/Case Series Actionable In a clinical case study, a leukemia patient with FLT3-ITD positive leukemia initially responded to Pexidartinib (PLX3397), but experienced relapse after emergence of a compound FLT3 M837G/S838R/D839H mutation on the FLT3-ITD allele (PMID: 25847190). 25847190
Clinical Trial Phase Therapies Title Recruitment Status