Molecular Profile Detail


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Profile Name FLT3 exon 14 ins FLT3 F691L FLT3 D839N
Gene Variant Detail

FLT3 D839N (unknown)

FLT3 exon 14 ins (gain of function - predicted)

FLT3 F691L (no effect - predicted)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 F691L FLT3 D839N Advanced Solid Tumor resistant Pexidartinib Preclinical Actionable In a preclinical study, transformed cells expressing a compound FLT3-ITD/F691L/D839N were resistant to PLX3397 in culture (PMID: 25847190). 25847190