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|Profile Name||TSC1 del|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|TSC1 del||urinary bladder cancer||sensitive||Metformin||Preclinical||Actionable||In a preclinical study, bladder cancer cells harboring a deletion of TSC1 were sensitive to Glucophage (metformin) in culture, resulting in cell growth inhibition (PMID: 26921394).||26921394|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|