Molecular Profile Detail


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Profile Name KMT2A - MLLT1
Gene Variant Detail

KMT2A - MLLT1 (gain of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A - MLLT1 acute lymphoblastic leukemia predicted - sensitive I-BET151 + Prednisolone Preclinical - Cell culture Actionable In a preclinical study, treatment with I-BET151 enhanced the efficacy of Omnipred (prednisolone) in acute lymphoblastic leukemia cells harboring a KMT2A-MLLT1 (also known as MLL-ENL) fusion, resulting in increased cell death compared to either therapy alone in culture (PMID: 29748211). 29748211
KMT2A - MLLT1 acute myeloid leukemia sensitive MI-503 Preclinical - Cell culture Actionable In a preclinical study, MI-503 inhibited growth of an acute myeloid leukemia cell line harboring KMT2A-MLLT1 (MLL-ENL) in culture (PMID: 25817203). 25817203
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries