Molecular Profile Detail

Profile Name KRAS mut STK11 inact mut
Gene Variant Detail

KRAS mutant (unknown)

STK11 inact mut (loss of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mut STK11 inact mut non-small cell lung carcinoma sensitive SAR245409 Preclinical - Cell line xenograft Actionable In a preclinical study, a non-small cell lung carcinoma cell line harboring a KRAS mutation and STK11 inactivating mutation was sensitive to XL765 (SAR245409), demonstrating inhibition of cell proliferation in culture, and inhibition of tumor growth in cell line xenograft models (PMID: 24634413). 24634413
KRAS mut STK11 inact mut non-small cell lung carcinoma predicted - sensitive MK-1775 + Cisplatin Preclinical - Cell culture Actionable In a preclinical study, MK-1775 and Platinol (cisplatin) combination treatment demonstrated enhanced growth inhibition in non-small cell lung carcinoma cell lines harboring KRAS mutations and STK11 inactivating mutations compared to cells expressing wild-type STK11 in culture (PMID: 28652249). 28652249
KRAS mut STK11 inact mut non-small cell lung carcinoma predicted - sensitive Adavosertib Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung carcinoma cell lines harboring KRAS mutations and STK11 inactivating mutations demonstrated increased sensitivity to MK-1775 compared to cells expressing wild-type STK11 in culture (PMID: 28652249). 28652249
KRAS mut STK11 inact mut lung adenocarcinoma sensitive MLN0128 + Phenformin Preclinical Actionable In a preclinical study, Sapanisertib (MLN0128) in combination with phenformin induced apoptosis and energetic stress in human lung adenocarcinoma cell lines with concurrent KRAS and STK11 (LKB1) mutations in culture, with higher levels than either therapy as a single agent (PMID: 26574479). 26574479
KRAS mut STK11 inact mut non-small cell lung carcinoma predicted - sensitive MK-1775 + Radiotherapy Preclinical - Cell culture Actionable In a preclinical study, MK-1775 combined with radiation therapy demonstrated enhanced growth inhibition in non-small cell lung carcinoma cell lines harboring KRAS mutations and STK11 inactivating mutations compared to cells expressing wild-type STK11 in culture (PMID: 28652249). 28652249
Clinical Trial Phase Therapies Title Recruitment Status