Molecular Profile Detail

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Profile Name CALR L367fs
Gene Variant Detail

CALR L367fs (gain of function)

Relevant Treatment Approaches JAK2 Inhibitor - ATP competitive

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
CALR L367fs hematologic cancer sensitive JAK2 Inhibitor - ATP competitive Ruxolitinib + Temsirolimus Preclinical - Cell culture Actionable In a preclinical study, Jakafi (ruxolitinib) and Torisel (temsirolimus) acted synergistically to inhibit growth of transformed cells expressing CALR L367fs in culture (PMID: 26668133). 26668133
CALR L367fs myelofibrosis not applicable N/A Guideline Prognostic The presence of the CALR type 1 mutation, L367fs, or a type 1-like mutation is associated with improved overall survival compared to a CALR type 2 (K385fs) or CALR type 2-like mutation and JAK2 V617F in patients with myelofibrosis (NCCN.org). detail...
CALR L367fs myelofibrosis predicted - sensitive JAK2 Inhibitor - ATP competitive Fedratinib Case Reports/Case Series Actionable In a clinical study, two myelofibrosis patients harboring CALR L367fs (reported as L367fs*46 for patient 1 and L367fs*48 for patient 2) and wild-type JAK2 demonstrated a greater than 50% reduction in spleen size following treatment with Inrebic (fedratinib) (PMID: 24645956). 24645956
CALR L367fs hematologic cancer sensitive JAK2 Inhibitor - ATP competitive Ruxolitinib Preclinical - Cell culture Actionable In a preclinical study, Jakafi (ruxolitinib) inhibited growth of transformed cells expressing CALR L367fs in culture (PMID: 26668133). 26668133
Clinical Trial Phase Therapies Title Recruitment Status