Molecular Profile Detail

Profile Name ETV6-ROS1
Gene Variant Detail

ETV6 ETV6 - ROS1 (gain of function - predicted)

Relevant Treatment Approaches ROS1 Inhibitor

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ETV6-ROS1 Advanced Solid Tumor sensitive ROS1 Inhibitor Entrectinib Preclinical - Cell line xenograft Actionable In a preclinical study, transformed cells expressing ETV6-ROS1 were sensitive to Entrectinib (RXDX-101), resulting in inhibition of cell proliferation in culture and decreased tumor growth in xenograft models (PMID: 26939704). 26939704
Clinical Trial Phase Therapies Title Recruitment Status