Molecular Profile Detail

Profile Name BRAF V600E KRAS mutant
Gene Variant Detail

BRAF V600E (gain of function)

KRAS mutant (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E KRAS mutant colorectal cancer resistant PD-0325901 Preclinical Actionable In a preclinical study, over expression of BRAF V600E in KRAS-mutant colorectal cancer cells resulted in resistance to growth inhibition by PD-0325901 in cell culture (PMID: 26267534). 26267534
BRAF V600E KRAS mutant colorectal cancer sensitive DEL-22379 Preclinical - Cell culture Actionable In a preclinical study, DEL-22379 inhibited growth of KRAS-mutant melanoma cells over expressing BRAF V600E in culture (PMID: 26267534). 26267534
Clinical Trial Phase Therapies Title Recruitment Status