Molecular Profile Detail


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Profile Name IKZF1 del
Gene Variant Detail

IKZF1 del (loss of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
IKZF1 wild-type multiple myeloma sensitive Lenalidomide Preclinical Actionable In a preclinical study, Revlimid (lenalidomide) treatment resulted in IKZF1 degradation and decreased proliferation of multiple myeloma cells in culture (PMID: 24292625). 24292625
IKZF1 del acute lymphoblastic leukemia not applicable N/A Clinical Study Prognostic In multiple clinical studies, including a meta-analysis, IKZF1 deletion was associated with a worse event-free survival and overall survival in patients with acute lymphocytic leukemia (PMID: 25335741, PMID: 26194343, PMID: 27067989). 25335741 26194343 27067989
Clinical Trial Phase Therapies Title Recruitment Status