Molecular Profile Detail

Profile Name MAP2K1 Y134C KRAS Q61H
Gene Variant Detail

KRAS Q61H (loss of function)

MAP2K1 Y134C (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 Y134C KRAS Q61H lung adenocarcinoma no benefit Refametinib Preclinical Actionable In a preclinical study, treatment with Refametanib (BAY86-9766) had no effect on a lung adenocarcinoma cell line co-harboring MAP2K1 Y134C and KRAS Q61H in culture (PMID: 26582713). 26582713
MAP2K1 Y134C KRAS Q61H lung adenocarcinoma no benefit Trametinib Preclinical Actionable In a preclinical study, treatment with Mekinist (trametinib) had no effect on a lung adenocarcinoma cell line co-harboring MAP2K1 Y134C and KRAS Q61H in culture (PMID: 26582713). 26582713
Clinical Trial Phase Therapies Title Recruitment Status