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|Profile Name||U2AF1 S34F|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|U2AF1 S34F||acute myeloid leukemia||sensitive||E7107||Preclinical - Patient cell culture||Actionable||In a preclinical study, patient-derived acute myeloid leukemia cells harboring U2AF1 S34F were sensitive to E7107 in cell culture (PMID: 28067246).||28067246|
|U2AF1 S34F||lung cancer||sensitive||H3B-8800||Preclinical - Cell line xenograft||Actionable||In a preclinical study, H3B-8800 preferentially inhibited growth of lung cancer cells harboring U2AF1 S34F compared to U2AF1 wild-type cells in culture and in cell line xenograft models (Cancer Res 2017;77(13 Suppl):Abstract nr 1185).||detail...|
|U2AF1 S34F||acute myeloid leukemia||sensitive||Sudemycin D6||Preclinical||Actionable||In a preclinical study, Sudemycin D6 treatment induced cell cycle arrest and growth inhibition in acute myeloid leukemia cell lines expressing U2AF1 S34F in culture, and inhibited progenitor cells expansion in transgenic mouse models (PMID: 28067246).||28067246|
|U2AF1 S34F||acute myeloid leukemia||sensitive||Indisulam||Preclinical - Cell culture||Actionable||In a preclinical study, an acute myeloid leukemia cell line engineered to express U2AF1 S34F from the endogenous locus demonstrated increased sensitivity to Indisulam (E7070) induced growth inhibition compared to parental cells in culture (PMID: 30799057).||30799057|
|U2AF1 S34F||acute myeloid leukemia||sensitive||E7820||Preclinical - Cell culture||Actionable||In a preclinical study, an acute myeloid leukemia cell line engineered to express U2AF1 S34F from the endogenous locus demonstrated increased sensitivity to E7820 induced growth inhibition compared to parental cells in culture (PMID: 30799057).||30799057|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|