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|Profile Name||ATRX inact mut|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ATRX inact mut||Advanced Solid Tumor||sensitive||E7449||Preclinical||Actionable||In a preclinical study, E7449 inhibited proliferation of a ATRX-deficient cell line in culture, which demonstrated increased sensitivity compared to cells without DNA repair pathway mutations (PMID: 26513298).||26513298|
|ATRX inact mut||prostate cancer||predicted - sensitive||Olaparib||Case Reports/Case Series||Actionable||In a Phase II (TOPARP-B) trial, Lynparza (olaparib) treatment resulted in a composite overall response rate of 20.0% (4/20) and a RECIST objective response rate of 0% (0/17) in patients with castration-resistant prostate cancer harboring deleterious mutations in DNA damage response genes, including ARID1A, ATRX, CHEK1/2, FANCA, FANCF, FANCG, FANCI, FANCM, MSH2, NBN, RAD50, and WRN (n=1, 1, 1, 5, 5, 2, 1, 1, 2, 1, 1, 1, 7, respectively) (PMID: 31806540; NCT01682772).||31806540|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT03209401||Phase I||Carboplatin + Niraparib||Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies||Recruiting|
|NCT04266912||Phase Ib/II||Avelumab + Berzosertib||Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors||Recruiting|
|NCT02278250||Phase I||VX-803 Carboplatin + VX-803||An Open-Label Study of the Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Profile of M4344 (Formerly VX-803) as a Single Agent and in Combination With Cytotoxic Chemotherapy in Participants With Advanced Solid Tumors||Recruiting|