Molecular Profile Detail

Profile Name KIT K550_W557del
Gene Variant Detail

KIT K550_W557del (gain of function - predicted)

Relevant Treatment Approaches KIT Inhibitor

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT K550_W557del Advanced Solid Tumor sensitive KIT Inhibitor Regorafenib Preclinical Actionable In a preclinical study, transformed cells expressing KIT K550_W557del demonstrated sensitivity to treatment with Stivarga (regorafenib) in culture, resulting in reduced cell viability (PMID: 25239608). 25239608
KIT K550_W557del Advanced Solid Tumor sensitive KIT Inhibitor Imatinib Preclinical Actionable In a preclinical study, transformed cells expressing KIT K550_W557del demonstrated sensitivity to treatment with Gleevec (imatinib) in culture, resulting in reduced cell viability (PMID: 25239608). 25239608
KIT K550_W557del Advanced Solid Tumor sensitive KIT Inhibitor Ponatinib Preclinical Actionable In a preclinical study, transformed cells expressing KIT K550_W557del demonstrated sensitivity to treatment with Iclusig (ponatinib) in culture, resulting in reduced cell viability (PMID: 25239608). 25239608
KIT K550_W557del Advanced Solid Tumor sensitive KIT Inhibitor Sunitinib Preclinical Actionable In a preclinical study, transformed cells expressing KIT K550_W557del demonstrated sensitivity to treatment with Sutent (sunitinib) in culture, resulting in reduced cell viability (PMID: 25239608). 25239608
Clinical Trial Phase Therapies Title Recruitment Status