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|Profile Name||MAP2K1 Q56_V60del|
|Gene Variant Detail|
|Relevant Treatment Approaches||MEK inhibitor (Pan) MEK1 Inhibitor|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|MAP2K1 Q56_V60del||ovarian serous carcinoma||predicted - sensitive||MEK inhibitor (Pan) MEK1 Inhibitor||Selumetinib||Case Reports/Case Series||Actionable||In a Phase II trial, Koselugo (selumetinib) treatment resulted in a complete response that lasted over 5 years with continuous treatment in a patient with serous ovarian cancer harboring MAP2K1 Q56_V60del (PMID: 26324360).||26324360|