Molecular Profile Detail


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Profile Name EZH2 over exp
Gene Variant Detail

EZH2 over exp (no effect)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
EZH2 over exp lung non-small cell carcinoma sensitive JQEZ5 Preclinical Actionable In a preclinical study, JQEZ5 inhibited proliferation of human EZH2-overexpressing non-small cell lung cancer cells in culture and induced tumor regression in mouse models of EZH2-overexpressing lung adenocarcinoma (PMID: 27312177). 27312177
EZH2 over exp medulloblastoma predicted - sensitive MC3629 Preclinical - Cell line xenograft Actionable In a preclinical study, MC3629 decreased proliferation and induced apoptosis in human and mouse primary SHH-subgroup medulloblastoma (SHH-MB) derived stem-cell like cells expressing high EZH2 levels in culture, decreased viability of a human SHH-MB cell line expressing high EZH2 in culture, and increased apoptosis and decreased growth of human SHH-MB cell line derived stem-cell like cells in culture and in xenograft models (PMID: 28978137). 28978137
Clinical Trial Phase Therapies Title Recruitment Status