Molecular Profile Detail

Profile Name PDGFRA H845_N848delinsP
Gene Variant Detail

PDGFRA H845_N848delinsP (gain of function)

Relevant Treatment Approaches PDGFR Inhibitor (Pan) PDGFR-alpha Inhibitor

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PDGFRA H845_N848delinsP gastrointestinal stromal tumor predicted - sensitive PDGFR Inhibitor (Pan) Imatinib Case Reports/Case Series Actionable In a clinical case study, Gleevec (imatinib) treatment resulted in a complete metabolic response in all lesions in a patient with gastric gastrointestinal stromal tumor harboring PDGFRA H845_N848delinsP (PMID: 30778083). 30778083
PDGFRA H845_N848delinsP Advanced Solid Tumor sensitive PDGFR Inhibitor (Pan) Imatinib Preclinical - Cell culture Actionable In a preclinical study, Gleevec (imatinib) inhibited Pdgfra phosphorylation in transformed cells over expressing PDGFRA H845_N848delinsP in culture (PMID: 21224473). 21224473
Clinical Trial Phase Therapies Title Recruitment Status