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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ERBB2 A775_G776insYVMA||lung adenocarcinoma||predicted - sensitive||Ado-trastuzumab emtansine||Case Reports/Case Series||Actionable||In a Phase II trial, treatment with Kadcyla (trastuzumab emtansine) resulted in best overall responses of partial response in 44% (8/18) and stable disease in 39% (7/18), and median progression-free survival of 5 months in patients with lung adenocarcinoma harboring ERBB2 (HER2) activating mutations, and a subset of patients specifically harboring ERBB2 (HER2) A775_G776insYVMA mutation had a 60% (3/5) partial response rate (PMID: 29989854; NCT02675829).||29989854|
|ERBB2 A775_G776insYVMA||lung non-small cell carcinoma||sensitive||HER2 Inhibitor||Pyrotinib||Case Reports/Case Series||Actionable||In a Phase II trial, ten patients with non-small cell lung cancer harboring ERBB2 A775_G776insYVMA demonstrated an objective response rate of 50% (5/10) and a progression-free survival of 4.1 months when treated with Pyrotinib, and preclinical analysis showed Pyrotinib treatment led to reduced cell viability in patient-derived organoids and tumor growth inhibition and regression in patient derived xenograft (PDX) models (PMID: 30596880; NCT02535507).||30596880|
|ERBB2 A775_G776insYVMA||lung non-small cell carcinoma||sensitive||Ado-trastuzumab emtansine||Preclinical - Pdx||Actionable||In a preclinical study, treatment with Kadcyla (ado-trastuzumab emtansine) resulted in tumor growth inhibition and tumor regression of patient derived xenograft (PDX) models harboring ERBB2 A775_G776insYVMA, but to a lesser degree than treatment with Pyrotinib (PMID: 30596880; NCT02535507).||30596880|
|ERBB2 A775_G776insYVMA||lung non-small cell carcinoma||sensitive||HER inhibitor (Pan)||Afatinib||Preclinical - Pdx & cell culture||Actionable||In a preclinical study, treatment with Gilotrif (afatinib) resulted in decreased cell viability of patient-derived non-small cell lung cancer organoids harboring ERBB2 A775_G776insYVMA and tumor growth inhibition and tumor regression in patient derived xenograft (PDX) models, but to a lesser degree than treatment with Pyrotinib (PMID: 30596880; NCT02535507).||30596880|
|ERBB2 A775_G776insYVMA||Advanced Solid Tumor||sensitive||JQ1 + Osimertinib||Preclinical||Actionable||In a preclinical study, transgenic mouse models expressing ERBB2 (HER2) A775_G776insYVMA demonstrated greater tumor regression when treated with the combination of JQ1 and Tagrisso (osimertinib) compared to treatment with either agent alone, which resulted in little to no regression (PMID: 29298799).||29298799|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|