Molecular Profile Detail

Profile Name BRAF wild-type KRAS G13D
Gene Variant Detail

BRAF wild-type (no effect)

KRAS G13D (loss of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF wild-type KRAS G13D colon cancer resistant GDC0879 Preclinical - Cell line xenograft Actionable In a preclinical study, GDC0879 failed to inhibit growth of BRAF wild-type colon cancer cells harboring KRAS G13D in culture ann in cell line xenograft models (PMID: 19276360). 19276360
Clinical Trial Phase Therapies Title Recruitment Status