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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|TP53 V173M||acute myeloid leukemia||predicted - sensitive||p53 Activator||APR-246||Phase I||Actionable||In a Phase I clinical trial, APR-246 demonstrated safety and preliminary clinical activity in patients with hematological cancers, including an acute myeloid leukemia patient harboring TP53 V173M that achieved a decrease in bone marrow blast percentage from 46% to 26% (PMID: 22965953).||22965953|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|