Molecular Profile Detail

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Profile Name KDR pos RET C634W
Gene Variant Detail

KDR positive (unknown)

RET C634W (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KDR pos RET C634W thyroid gland medullary carcinoma predicted - sensitive Motesanib Diphosphate Preclinical - Cell line xenograft Actionable In a preclinical study, Motesanib (AMG 706) inhibited KDR (VEGFR2) phosphorylation, but had minimal activity against RET in a medullary thyroid carcinoma (MTC) cell line harboring RET C634W in culture, however, inhibited both RET and KDR (VEGFR2) phosphorylation and decreased tumor angiogenesis and growth in MTC cell line xenograft models with RET C634W (PMID: 21422803). 21422803
Clinical Trial Phase Therapies Title Recruitment Status