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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KDR pos RET C634W||thyroid gland medullary carcinoma||predicted - sensitive||Motesanib Diphosphate||Preclinical - Cell line xenograft||Actionable||In a preclinical study, Motesanib (AMG 706) inhibited KDR (VEGFR2) phosphorylation, but had minimal activity against RET in a medullary thyroid carcinoma (MTC) cell line harboring RET C634W in culture, however, inhibited both RET and KDR (VEGFR2) phosphorylation and decreased tumor angiogenesis and growth in MTC cell line xenograft models with RET C634W (PMID: 21422803).||21422803|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|