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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PDGFRA V561D PDGFRA D842V||gastrointestinal stromal tumor||resistant||Imatinib||Case Reports/Case Series||Actionable||In a clinical study, PDGFRA D842V was identified as a secondary mutation in a patient with gastrointestinal stromal tumor harboring a primary PDGFRA V561D mutation, who developed resistance to Gleevec (imatinib mesylate) (PMID: 16954519).||16954519|
|PDGFRA V561D PDGFRA D842V||Advanced Solid Tumor||resistant||Sunitinib||Preclinical - Cell culture||Actionable||In a preclinical study, PDGFRA D842V conferred resistance to inhibition of PDGFRA phosphorylation by Sutent (sunitinib) in cells expressing PDGFRA V561D in culture (PMID: 18955458).||18955458|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|