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Profile Name | APC E853* |
Gene Variant Detail | |
Relevant Treatment Approaches | CTNNB1 Inhibitor Tankyrase Inhibitor |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC E853* APC K1555* | colorectal cancer | sensitive | TASIN-1 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TASIN-1 efficiently inhibited survival of colorectal cancer cells harboring APC E853* and APC K1555* in culture and inhibited tumor growth in xenograft models (PMID: 27798265). | 27798265 |
APC E853* APC T1556fs | colorectal cancer | resistant | G007-LK | Preclinical - Cell culture | Actionable | In a preclinical study, a colorectal cancer cell line harboring APC E853* and APC T1556fs (reported as APC T1556fs*3) demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with G007-LK in culture (PMID: 28179481). | 28179481 |
APC E853* APC T1556fs | colorectal cancer | resistant | IWR-1 | Preclinical - Cell culture | Actionable | In a preclinical study, a colorectal cancer cell line harboring APC E853* and APC T1556fs (reported as APC T1556fs*3) demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with IWR-1 in culture (PMID: 28179481). | 28179481 |
APC E853* APC T1556fs | colorectal cancer | resistant | XAV939 | Preclinical - Cell culture | Actionable | In a preclinical study, a colorectal cancer cell line harboring APC E853* and APC T1556fs (reported as APC T1556fs*3) demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with XAV939 in culture (PMID: 28179481). | 28179481 |
APC E853* APC T1556Nfs*3 | colorectal cancer | sensitive | STP1002 | Preclinical - Cell culture | Actionable | In a preclinical study, STP1002 inhibited Wnt/beta-catenin signaling and colony formation in a colorectal cancer cell line harboring APC E853* and APC T1556Nfs*3 in culture (PMID: 35849876). | 35849876 |