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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EML4 - ALK ALK F1174V||lung non-small cell carcinoma||predicted - sensitive||Alectinib||Alectinib||Case Reports/Case Series||Actionable||In a clinical case study, a non-small cell lung carcinoma patient harboring EML4-ALK initially responded to Xalkori (crizotinib), but then progressed due to acquisition of the secondary resistance mutation, ALK F1174V, and then responded to treatment with Alecensa (alectinib), demonstrating a complete response in one lung nodule and a 44% decrease in size in a second lung nodule (PMID: 26464158).||26464158|
|EML4 - ALK ALK F1174V||Advanced Solid Tumor||decreased response||Crizotinib||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells expressing ALK F1174V in the context of EML4-ALK demonstrated reduced sensitivity to Xalkori (crizotinib) compared to cells expressing EML4-ALK in culture (PMID: 27780853).||27780853|
|EML4 - ALK ALK F1174V||Advanced Solid Tumor||sensitive||Brigatinib||Brigatinib||Preclinical - Cell culture||Actionable||In a preclinical study, Alunbrig (brigatinib) inhibited growth of transformed cells expressing ALK F1174V in the context of EML4-ALK in culture (PMID: 27780853).||27780853|
|EML4 - ALK ALK F1174V||lung non-small cell carcinoma||resistant||Crizotinib||Clinical Study||Actionable||In a clinical case study, a patient with non-small cell lung carcinoma harboring EML4-ALK demonstrated a partial response to Xalkori (crizotinib) treatment after 3 months, but then progressed, and was found to harbor the secondary resistance mutation, ALK F1174V (PMID: 24736079).||24736079|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|