Molecular Profile Detail

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Profile Name NPM1 exon12
Gene Variant Detail

NPM1 exon12 (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
NPM1 exon12 acute myeloid leukemia sensitive Deguelin Preclinical Actionable In preclinical studies, deguelin treatment of an AML cell line harboring NPM1 exon12 mutation resulted in reduced levels of mutant Npm1 protein and induced differentiation of the cells (PMID: 25242579, PMID: 25348016). 25242579 25348016
NPM1 exon12 acute myeloid leukemia predicted - sensitive Ixazomib Case Reports/Case Series Actionable In a clinical study, Ixazomib (MLN9708) treatment resulted in significantly reduced peripheral blast cells in a NPMc+ (due to NPM1 exon 12 mutations) acute myeloid leukemia (AML) patient, and demonstrated selective toxicity towards NPMc+ AML cell lines in culture (PMID: 26634271). 26634271
NPM1 exon12 acute myeloid leukemia sensitive Ixazomib + Vorinostat Preclinical - Cell culture Actionable In a preclinical study, Ixazomib (MLN9708) and Zolinza (vorinostat) synergistically induced apoptosis in NPMc+ (due to NPM1 exon 12 mutations) acute myeloid leukemia cells in culture (PMID: 26634271). 26634271
Clinical Trial Phase Therapies Title Recruitment Status