Molecular Profile Detail


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Profile Name TP53 C242fs
Gene Variant Detail

TP53 C242fs (loss of function - predicted)

Relevant Treatment Approaches p53 Gene Therapy


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 C242fs acute myeloid leukemia predicted - sensitive thioureidobutyronitrile Preclinical - Cell culture Actionable In a preclinical study, Kevetrin (thioureidobutyronitrile) treatment resulted in apoptosis, decreased cell viability, altered cell cycle progression, elevated expression of Tp53 target genes, and increased Tp53 nuclear localization in an acute myeloid leukemia cell line harboring TP53 C242fs in culture (PMID: 32945487). 32945487
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries