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|Profile Name||SETBP1 mutant|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|SETBP1 mutant||myelodysplastic/myeloproliferative neoplasm||not applicable||N/A||Preclinical||Emerging||In a preclinical study, SETPB1 missense mutations conferred a predicted gain-of-function, resulting in transformation of murine myeloid progenitors and increased Pp2ac phosphorylation compared to wild-type SETBP1 in culture, suggesting that Setbp1 may serve as a potential therapeutic target (PMID: 23832012).||23832012|
|SETBP1 mutant||myelodysplastic syndrome||not applicable||N/A||Clinical Study||Prognostic||In clinical analyses, mutations in SETBP1 were associated with poor prognosis in patients with myelodysplastic syndrome (PMID: 28447248, PMID: 28158286, PMID: 24127063, PMID: 23889083, PMID: 23832012).||23889083 24127063 28447248 23832012 28158286|
|SETBP1 mutant||chronic myelomonocytic leukemia||not applicable||N/A||Clinical Study||Prognostic||In clinical analyses, mutations in SETBP1 were associated with poor prognosis in patients with chronic myelomonocytic leukemia (PMID: 29225884, PMID: 28158286, PMID: 28209919, PMID: 23558523, PMID: 23832012).||29225884 28209919 23832012 23558523 28158286|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|