Molecular Profile Detail

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Profile Name CDKN2A negative
Gene Variant Detail

CDKN2A negative (loss of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDKN2A negative lung non-small cell carcinoma predicted - sensitive Palbociclib Phase II Actionable In a Phase II trial, Ibrance (palbociclib) treatment resulted in no objective response (0/16) and stable disease in 50% (8/16) of patients with advanced Cdkn2a-null (by IHC) non-small cell lung cancer, with a median overall survival (mOS) of 5.1 months for all patients and a mOS of 16.6 months in patients achieved stable disease (PMID: 30647837; NCT01291017). 30647837
CDKN2A negative lung non-small cell carcinoma sensitive Everolimus + Palbociclib Preclinical - Cell culture Actionable In a preclinical study, Ibrance (palbociclib) and Afinitor (everolimus) synergisticaly inhibited growth of Cdkn2a-null non-small cell lung cancer cell lines in culture (PMID: 30647837). 30647837
CDKN2A negative lung non-small cell carcinoma sensitive Palbociclib + Sirolimus Preclinical - Cell culture Actionable In a preclinical study, Ibrance (palbociclib) and Rapamune (sirolimus) synergisticaly inhibited growth of Cdkn2a-null non-small cell lung cancer cell lines in culture (PMID: 30647837). 30647837
CDKN2A negative lung non-small cell carcinoma sensitive Palbociclib + PF-04691502 Preclinical - Cell culture Actionable In a preclinical study, Ibrance (palbociclib) and PF-04691502 synergisticaly inhibited growth of Cdkn2a-null non-small cell lung cancer cell lines in culture (PMID: 30647837). 30647837
CDKN2A negative head and neck squamous cell carcinoma predicted - sensitive Cetuximab + Palbociclib Case Reports/Case Series Actionable In a Phase I trial, Erbitux (cetuximab) and Ibrance (palbociclib) combination therapy was safe and resulted in a disease control rate of 89% (8/9, 2 partial responses, 6 stable disease) in patients with recurrent or metastatic head and neck squamous cell carcinoma, both responders had CDKN2A-negative tumors (PMID: 27311401). 27311401