Molecular Profile Detail


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Profile Name PBRM1 loss
Gene Variant Detail

PBRM1 loss (loss of function)

Relevant Treatment Approaches EZH2 inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PBRM1 loss melanoma sensitive unspecified CTLA4 antibody + unspecified PD-1 antibody Preclinical - Cell line xenograft Actionable In a preclinical study, knocking-out PBRM1 in melanoma cells sensitized cells to immune therapy consisted of anti-CTLA4 and anti-PD-1 antibodies in culture and in cell line xenograft models, potentially due to increased sensitivity to T cell-mediated cytotoxicity and a favorable tumor microenvironment (PMID: 29301958). 29301958
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries