Molecular Profile Detail


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Profile Name ERBB2 M774delinsWLV
Gene Variant Detail

ERBB2 M774delinsWLV (gain of function)

Relevant Treatment Approaches HER inhibitor (Pan) HER2 Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 M774delinsWLV lung adenocarcinoma sensitive HER inhibitor (Pan) Dacomitinib Case Reports/Case Series Actionable In a Phase II trial, a lung adenocarcinoma patient harboring ERBB2 (HER2) M774delinsWLV demonstrated a partial response to treatment with Vizimpro (dacomitinib) (PMID: 25899785; NCT00818441). 25899785
ERBB2 M774delinsWLV Advanced Solid Tumor sensitive HER inhibitor (Pan) Dacomitinib Preclinical - Cell culture Actionable In a preclinical study, Vizimpro (dacomitinib) inhibited growth of transformed cells expressing ERBB2 (HER2) M774delinsWLV in culture (PMID: 28363995). 28363995
Clinical Trial Phase Therapies Title Recruitment Status