Molecular Profile |
Indication/Tumor Type |
Response Type |
Relevant Treatment Approaches |
Therapy Name |
Approval Status |
Evidence Type |
Efficacy Evidence |
References |
APC L665* APC R1450*
|
colorectal cancer
|
resistant |
|
G007-LK
|
Preclinical - Cell culture |
Actionable |
In a preclinical study, a colorectal cancer cell line harboring APC L665* and APC R1450* demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with G007-LK in culture (PMID: 28179481).
|
28179481
|
APC L665* APC R1450*
|
colorectal cancer
|
sensitive |
|
XAV939
|
Preclinical - Cell culture |
Actionable |
In a preclinical study, a colorectal cancer cell line harboring APC L665* and APC R1450* demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with XAV939 in culture (PMID: 28179481).
|
28179481
|
APC L665* APC R1450*
|
colorectal cancer
|
sensitive |
|
IWR-1
|
Preclinical - Cell culture |
Actionable |
In a preclinical study, a colorectal cancer cell line harboring APC L665* and APC R1450* demonstrated low levels of Tcf/LEF activity, and was resistant to treatment with IWR-1 in culture (PMID: 28179481).
|
28179481
|