Molecular Profile Detail

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Profile Name TP53 P98fs TP53 R175C TP53 S215G
Gene Variant Detail

TP53 P98fs (loss of function - predicted)

TP53 R175C (no effect)

TP53 S215G (loss of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 P98fs TP53 R175C TP53 S215G ovarian cancer predicted - resistant Adavosertib + Carboplatin Case Reports/Case Series Actionable In a Phase II trial, Paraplatin (carboplatin) and Adavosertib (MK-1775) combination treatment resulted in disease progression in an ovarian cancer patient harboring TP53 P98fs, R175C, and S215G (PMID: 27998224). 27998224
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries