Molecular Profile Detail

Profile Name MET amp MET del exon14 MET D1228N MET G1163R MET L1195V
Gene Variant Detail

MET amp (no effect)

MET D1228N (gain of function)

MET del exon14 (gain of function)

MET G1163R (unknown)

MET L1195V (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MET amp MET del exon14 MET D1228N MET G1163R MET L1195V lung adenocarcinoma resistant Glesatinib Clinical Study Actionable In a clinical case study, a lung adenocarcinoma patient previously harboring MET amp, MET deletion exon 14, MET D1228N, MET Y1230H, MET Y1230S, and MET G1163R demonstrated a decrease in lesion size when treated with Glesatinib (MGCD265), however, progression ensued and plasma testing indicated the patient lost Y1230H and Y1230S, but acquired MET L1195V (PMID: 28765324). 28765324
Clinical Trial Phase Therapies Title Recruitment Status