Molecular Profile Detail

Profile Name KIT T670I KIT V560D
Gene Variant Detail

KIT T670I (gain of function)

KIT V560D (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT T670I KIT V560D Advanced Solid Tumor resistant Flumatinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells co-expressing KIT V560D and KIT T670I were resistant to Flumatinib in culture (PMID: 24205792). 24205792
KIT T670I KIT V560D Advanced Solid Tumor sensitive Motesanib Preclinical - Cell culture Actionable In a preclinical study, Motesanib (AMG 706) inhibited KIT phosphorylation and growth of cells expressing a KIT V560D/T670I double mutation in culture (PMID: 20633291). 20633291
Clinical Trial Phase Therapies Title Recruitment Status