Molecular Profile Detail

Profile Name BRAF wild-type KRAS wild-type
Gene Variant Detail

BRAF wild-type (no effect)

KRAS wild-type (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF wild-type KRAS wild-type colorectal cancer decreased response LSN3074753 Preclinical - Pdx Actionable In a preclinical study, LSN3074753 demonstrated limited efficacy in BRAF and KRAS wild-type patient-derived xenograft models of colorectal cancer, resulted in a disease control rate of 3.8% (1/26) (PMID: 28611205). 28611205
BRAF wild-type KRAS wild-type non-small cell lung carcinoma predicted - sensitive BMS-906024 + Paclitaxel Preclinical - Pdx & cell culture Actionable In a preclinical study, combination of BMS-906024 and Taxol (paclitaxel) resulted in synergy in BRAF and KRAS wild-type non-small cell lung cancer (NSCLC) cell lines in culture, but not in cell lines harboring KRAS or BRAF activating mutations, and demonstrated enhanced tumor growth inhibition in cell line and patient-derived xenograft (PDX) models of BRAF, KRAS wild-type NSCLC (PMID: 28978720). 28978720
Clinical Trial Phase Therapies Title Recruitment Status