Molecular Profile Detail

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Profile Name SRSF2 P95H
Gene Variant Detail

SRSF2 P95H (loss of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
SRSF2 P95H acute myeloid leukemia sensitive H3B-8800 Preclinical - Cell line xenograft Actionable In a preclinical study, H3B-8800 inhibited tumor growth in a cell line xenograft model of acute myeloid leukemia harboring SRSF2 P95H (PMID: 29457796). 29457796
SRSF2 P95H acute myeloid leukemia sensitive GSK3203591 + MS023 Preclinical - Patient cell culture Actionable In a preclinical study, GSK3203591 and MS023 synergistically inhibited survival of patient-derived acute myeloid leukemia cell lines harboring SRSF2 P95H in culture (PMID: 31408619). 31408619
SRSF2 P95H acute myeloid leukemia sensitive E7820 Preclinical - Cell culture Actionable In a preclinical study, an acute myeloid leukemia cell line engineered to express SRSF2 P95H from the endogenous locus demonstrated increased sensitivity to E7820 induced growth inhibition compared to parental cells in culture (PMID: 30799057). 30799057
SRSF2 P95H acute myeloid leukemia sensitive Indisulam Preclinical - Cell culture Actionable In a preclinical study, an acute myeloid leukemia cell line engineered to express SRSF2 P95H from the endogenous locus demonstrated increased sensitivity to Indisulam (E7070) induced growth inhibition compared to parental cells in culture (PMID: 30799057). 30799057
SRSF2 P95H chronic myeloid leukemia sensitive E7107 + GSK3203591 + MS023 Preclinical - Cell culture Actionable In a preclinical study, E7107, MS023, and GSK3203591 triple combination potently inhibited survival of a chronic myeloid leukemia cell line with knockin SRSF2 P95H in culture (PMID: 31408619). 31408619
SRSF2 P95H chronic myeloid leukemia sensitive GSK3203591 + MS023 Preclinical - Cell culture Actionable In a preclinical study, MS023 and GSK3203591 synergistically inhibited survival of a chronic myeloid leukemia cell line with knockin SRSF2 P95H in culture (PMID: 31408619). 31408619
Clinical Trial Phase Therapies Title Recruitment Status