Molecular Profile Detail

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Profile Name PALB2 del
Gene Variant Detail

PALB2 del (loss of function)

Relevant Treatment Approaches PARP Inhibitor (Pan)

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PALB2 del ovarian cancer sensitive AZD5305 Preclinical - Cell culture Actionable In a preclinical study, AZD5305 inhibited colony formation in an ovarian cancer cell line with PALB2 deletion in culture (PMID: 35929986). 35929986
PALB2 del uterus leiomyosarcoma predicted - sensitive PARP Inhibitor (Pan) Olaparib + Temozolomide Case Reports/Case Series Actionable In a clinical case study, Lynparza (olaparib) and Temodar (temozolomide) combination treatment resulted in stable disease and progression-free survival lasting 381 days in a patient with advanced uterine leiomyosarcoma harboring a homozygous deletion of PALB2 (PMID: 37467452). 37467452