Molecular Profile Detail

Profile Name CALR wild-type JAK2 wild-type MPL wild-type
Gene Variant Detail

CALR wild-type (no effect)

JAK2 wild-type (no effect)

MPL wild-type (no effect)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
CALR wild-type JAK2 wild-type MPL wild-type myelofibrosis not applicable N/A Guideline Prognostic The presence of concurrent wild-type JAK2, MPL, and CALR in myelofibrosis patients is associated with inferior leukemia-free survival compared to patients with JAK2 and/or CALR mutations, and is associated with inferior overall survival when compared to patients with CALR mutations ( detail...
Clinical Trial Phase Therapies Title Recruitment Status