Molecular Profile Detail


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Profile Name RET L629P RET D631_R635delinsG RET V637R
Gene Variant Detail

RET D631_R635delinsG (unknown)

RET L629P (unknown)

RET V637R (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET L629P RET D631_R635delinsG RET V637R thyroid gland medullary carcinoma predicted - sensitive Pralsetinib Case Reports/Case Series Actionable In a Phase I trial, a patient with medullary thryoid cancer harboring RET D631_R635delinsG, L629P, and V637R demonstrated a partial response, with maximal tumor reduction of 47% at 10 months, following treatment with Gavreto (pralsetinib) (PMID: 29657135; NCT03037385). 29657135
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries