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|Profile Name||RB1 H483Y|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RB1 H483Y||Her2-receptor negative breast cancer||predicted - resistant||Letrozole + Ribociclib||Case Reports/Case Series||Actionable||In a clinical case study, RB1 H48Y was identified in the circulating tumor DNA of a patient with estrogen receptor positive, progesterone receptor positive, and Erbb2 (Her2)-negative, invasive ductal carcinoma at the time of disease progression after 13 months of Kisqali (ribociclib) and Femara (letrozole) combination treatment (PMID: 29236940).||29236940|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|