Molecular Profile Detail

Profile Name AKT1 Q79K
Gene Variant Detail

AKT1 Q79K (gain of function)

Relevant Treatment Approaches Akt Inhibitor (Pan) Akt1 Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
AKT1 Q79K ovarian cancer predicted - sensitive Akt Inhibitor (Pan) Capivasertib Case Reports/Case Series Actionable In a Phase I trial, an ovarian cancer patient harboring AKT1 Q79K demonstrated tumor regression that lasted 14 months when treated with Capivasertib (AZD5363) (PMID: 28489509; NCT01226316). 28489509
Clinical Trial Phase Therapies Title Recruitment Status