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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KIT V559D KIT N822K||Advanced Solid Tumor||no benefit||Sunitinib||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells co-expressing KIT N822K and KIT V559D were insensitive to Sutent (sunitinib) in culture (PMID: 24205792).||24205792|
|KIT V559D KIT N822K||Advanced Solid Tumor||sensitive||Flumatinib||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells co-expressing KIT N822K and KIT V559D were sensitive to Flumatinib in culture, demonstrating decreased cell proliferation and inhibition of Kit, Erk 1/2, and Stat3 phosphorylation (PMID: 24205792).||24205792|