Molecular Profile Detail


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Profile Name KIT V559D KIT D820G
Gene Variant Detail

KIT D820G (unknown)

KIT V559D (gain of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT V559D KIT D820G Advanced Solid Tumor sensitive Flumatinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells co-expressing KIT D820G and KIT V559D were sensitive to Flumatinib in culture, demonstrating decreased cell proliferation (PMID: 24205792). 24205792
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries