Molecular Profile Detail

Profile Name AKT1 W80A
Gene Variant Detail

AKT1 W80A (no effect - predicted)

Relevant Treatment Approaches Akt Inhibitor (Pan) Akt1 Inhibitor

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
AKT1 W80A breast cancer resistant Akt Inhibitor (Pan) MK2206 Preclinical Actionable In a preclinical study, breast cancer cells expressing AKT1 W80A were resistant to MK2206 in culture, resulting in repression of induced cell death when compared to wild-type AKT1 (PMID: 25551293). 25551293
AKT1 W80A Advanced Solid Tumor resistant Akt Inhibitor (Pan) MK2206 Preclinical - Cell culture Actionable In a preclinical study, transformed mouse adipocytes expressing human Akt1 W80A were resistant to the AKT inhibitor, MK-2206 (PMID: 25856301). 25856301
Clinical Trial Phase Therapies Title Recruitment Status