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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EML4 - ALK NOTCH1 D1538A||lung non-small cell carcinoma||predicted - resistant||Brigatinib||Case Reports/Case Series||Actionable||In a clinical study, a non-small cell lung carcinoma patient harboring EML4-ALK demonstrated resistance to treatment with Alunbrig (brigatinib), and was subsequently found to have acquired NOTCH1 D1538A (PMID: 29636358).||29636358|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|