Molecular Profile Detail


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Profile Name ROS1 fusion KDR amp KIT amp PDGFRA amp
Gene Variant Detail

KDR amp (no effect)

KIT amp (no effect)

PDGFRA amp (no effect)

ROS1 fusion (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ROS1 fusion KDR amp KIT amp PDGFRA amp lung non-small cell carcinoma predicted - resistant Crizotinib Case Reports/Case Series Actionable In a clinical study, a non-small cell lung carcinoma patient harboring a ROS1 fusion treated with Xalkori (crizotinib) responded, but eventually progressed, and was subsequently found to harbor presumed resistance alterations, including amplification of KIT, KDR, and PDGFRA (PMID: 29636358). 29636358
Clinical Trial Phase Therapies Title Recruitment Status