Molecular Profile Detail


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Profile Name ROS1 fusion ERBB2 amp FGFR3 amp RET amp
Gene Variant Detail

ERBB2 amp (no effect)

FGFR3 amp (no effect)

RET amp (no effect)

ROS1 fusion (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ROS1 fusion ERBB2 amp FGFR3 amp RET amp lung non-small cell carcinoma predicted - resistant Crizotinib Case Reports/Case Series Actionable In a clinical study, a non-small cell lung carcinoma patient harboring a ROS1 fusion treated with Xalkori (crizotinib) responded, but eventually progressed, and was subsequently found to harbor presumed resistance alterations, including amplification of ERBB2 (HER2), FGFR3, and RET (PMID: 29636358). 29636358
Clinical Trial Phase Therapies Title Recruitment Status